Search targets, diseases & drugs
API · /opentargets-api
Open Targets API
healthy
3,941 Subscribers
Drug target–disease associations as an API, powered by the Open Targets Platform. Open Targets integrates human genetics, genomics, transcriptomics, known drugs, animal models and the scientific literature to systematically score how strongly a target (gene/protein) is associated with a disease — the evidence that underpins modern drug discovery. Search across targets, diseases and drugs; read a target for its approved symbol, biotype, function, genomic location and UniProt ids together with the diseases it is most strongly associated with and their overall association scores; read a disease for its description, therapeutic areas and its top associated targets with scores; and read a drug for its modality, maximum clinical stage, trade names, synonyms and mechanisms of action. Ideal for drug-discovery and target-identification pipelines, therapeutic-area research, biomedical data science and pharma intelligence tools. Target ids are Ensembl gene ids, disease ids are EFO/MONDO/Orphanet ids, drug ids are ChEMBL ids. Data is open (CC0).
#open-targets
#drug-discovery
#target-disease
#genetics
#therapeutics
#bioinformatics
#life-sciences
api.oanor.com/opentargets-api
API health
healthy- Uptime
- 100.00%
- Server probes · 24h
- Avg latency
- 342 ms
- Server probes · 24h
- Subscribers
- 3,941
- active
- Total calls
- 100
- last 7 days
Pricing
Pick a tier — billed monthly, cancel anytime.
Free
Free
- 520 calls / month
- 2 requests / second
- Hard cap (429 above quota, no overage)
- 520 calls/month
- 2 req/sec
- Search, targets & diseases
- No credit card
Starter
€7.45 /month
- 19,200 calls / month
- 6 requests / second
- Hard cap (429 above quota, no overage)
- 19.2k calls/month
- 6 req/sec
- Target & disease lookup
- Email support
Pro
€22.30 /month
- 87,800 calls / month
- 15 requests / second
- Hard cap (429 above quota, no overage)
- 87.8k calls/month
- 15 req/sec
- Target identification
- Priority support
Mega
€60.80 /month
- 336,000 calls / month
- 40 requests / second
- Hard cap (429 above quota, no overage)
- 336k calls/month
- 40 req/sec
- High-throughput drug discovery
- Dedicated SLA
Built by
Related APIs
Other APIs with overlapping tags.
ChEMBL API
The ChEMBL database of bioactive molecules as an API — the EBI's manually curated knowledgebase of drug-like compounds and their biological activity, powered by the official ChEMBL data API. Look up a compound by its ChEMBL id for its development phase, chemical structure (SMILES, InChIKey), molecular formula and weight, calculated properties (ALogP, polar surface area, hydrogen-bond donors/acceptors, Rule-of-Five violations, QED drug-likeness) and synonyms; search compounds by name; read a biological target with its organism and UniProt protein components; list a drug's mechanisms of action; list its approved and investigational indications (MeSH and EFO terms with development phase); and pull its measured bioactivities (IC50, Ki, EC50, potency…) with values, units, pChEMBL scores, assays and targets. Ideal for drug-discovery and cheminformatics pipelines, medicinal-chemistry and pharmacology tools, target-identification and SAR research, and life-science apps.
api.oanor.com/chembl-api
Population Genetics API
Population-genetics maths as an API, computed locally and deterministically. The hardy-weinberg endpoint applies the Hardy-Weinberg principle, p² + 2pq + q² = 1 — give a dominant allele frequency p, a recessive q, or the homozygous-recessive (affected) frequency q² and it returns all the allele and genotype frequencies, including the carrier frequency 2pq. The punnett endpoint crosses two parent genotypes and returns the offspring genotype and phenotype ratios, handling a single gene (a monohybrid 1:2:1 / 3:1 cross), two genes (a dihybrid 9:3:3:1 cross) and up to four genes by independent assortment. The carrier endpoint takes the incidence of a recessive disease — as a fraction or one-in-N — and returns the recessive allele frequency q = √incidence, the carrier frequency 2pq, the one-in-N carrier rate and, for a given population, the expected number of carriers and affected individuals. Everything is computed locally and deterministically, so it is instant and private. Ideal for genetics-education, genetic-counselling, breeding and biology app developers, inheritance and risk tools, and biology teaching. Pure local computation — no key, no third-party service, instant. Live, nothing stored. 3 endpoints. This is population genetics; for DNA sequence analysis use a DNA API.
api.oanor.com/genetics-api
DNA Sequence API
DNA/RNA sequence-analysis maths as an API, computed locally and deterministically. The analyze endpoint reports the length and base composition of a sequence, the GC and AT content, the complement, the reverse and the reverse complement (the opposite strand read 5'→3'), and the approximate single-stranded molecular weight. The translate endpoint transcribes DNA to mRNA (T→U) and translates it to protein with the standard genetic code in reading frame 1, 2 or 3, giving the one-letter amino-acid sequence, the protein length and the number of stop codons. The melting endpoint estimates a primer's melting temperature with the Wallace rule, 4·(G+C) + 2·(A+T), for short oligos and a salt-adjusted basic formula for longer ones. Sequences are case- and whitespace-insensitive and accept A, C, G, T for DNA or U for RNA. Everything is computed locally and deterministically, so it is instant and private. Ideal for bioinformatics, molecular-biology, genomics and lab app developers, primer-design and sequence-inspection tools, and biology education. Pure local computation — no key, no third-party service, instant. Live, nothing stored. 3 endpoints. This is sequence analysis; for genome assembly data use a genomes API.
api.oanor.com/dna-api
Polygenic Scores API
Polygenic (risk) scores as an API — powered by the NHGRI-EBI PGS Catalog, the open database of published polygenic scores: weighted combinations of genetic variants used to estimate a person's genetic predisposition to a trait or disease. Search traits by name to find their ontology ids, list every polygenic score developed for a trait, and read a score's full metadata — the reported and mapped (EFO/MONDO) traits, the number of variants in the score, the development method, genome build, the ancestry distribution of the samples it was built and evaluated on, the publication behind it (title, journal, date, PubMed id), the release date, license and a direct link to the scoring file. From breast cancer and coronary artery disease to type 2 diabetes and BMI, it is ideal for statistical genetics, genomics, risk-prediction research and bioinformatics tools. A polygenic-score / genetic-risk-prediction resource — distinct from single-variant association studies (GWAS Catalog), population allele frequencies (gnomAD) and clinical variant interpretation (ClinVar). Open data from the NHGRI-EBI PGS Catalog (CC BY 4.0).
api.oanor.com/pgs-api
Frequently asked questions
Quick answers about pricing, quotas, and integration.
How do I get an API key for Open Targets API?
Sign up for free at oanor.com, generate an API key from the developer dashboard, and call Open Targets API with the x-oanor-key header. No credit card needed for the free tier.
What's the rate limit for Open Targets API?
Free tier allows 1 request per second. Paid plans scale up to 50 requests per second on the Mega tier. Hard limits return HTTP 429 above the quota — no surprise overage charges.
How much does Open Targets API cost?
Open Targets API has a free tier with 100 calls / month. Paid plans start at €7.45 / month with higher quotas and faster rate limits.
Can I cancel my subscription anytime?
Yes. Plans are billed monthly and you can cancel anytime from your billing dashboard. No long-term contracts and no cancellation fee.
Is Open Targets API GDPR-compliant?
All requests to Open Targets API go through our EU-based gateway. Your upstream API key never leaves our server and no personal data is shared with the upstream provider beyond the request you send.
Pick an endpoint from the list on the left to see its details and try it.
Code snippets
Sign up to get an API key, then call any path under your slug.
curl https://api.oanor.com/opentargets-api/SOME_PATH \
-H "x-oanor-key: oanor_test_..."const res = await fetch("https://api.oanor.com/opentargets-api/SOME_PATH", {
headers: { "x-oanor-key": "oanor_test_..." }
});
const data = await res.json();$ch = curl_init("https://api.oanor.com/opentargets-api/SOME_PATH");
curl_setopt($ch, CURLOPT_RETURNTRANSFER, true);
curl_setopt($ch, CURLOPT_HTTPHEADER, ["x-oanor-key: oanor_test_..."]);
$response = curl_exec($ch);import requests
r = requests.get(
"https://api.oanor.com/opentargets-api/SOME_PATH",
headers={"x-oanor-key": "oanor_test_..."},
)
print(r.json())Ratings
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