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API · /interpro-api

InterPro API

healthy 4,610 Subscribers

Protein families, domains and functional sites as an API, powered by the EBI InterPro database. InterPro classifies proteins into families and identifies the domains, repeats and important sites they contain, by combining the predictive signatures of many member databases (Pfam, SMART, PROSITE, CDD, PANTHER, SUPERFAMILY, NCBIfam and more) into a single integrated resource. Look up an InterPro entry — a family, domain, repeat, conserved/binding/active site or post-translational modification — with its description, Gene Ontology terms and the member-database signatures that define it; search entries by name and type; read a protein's metadata; and, most usefully, list the InterPro entries found on a protein together with their start–end positions, so you can see a protein's domain architecture. Ideal for protein annotation and function prediction, comparative genomics, structural-biology and bioinformatics pipelines, and research and teaching tools. Entry ids are IPR followed by six digits; protein ids are UniProt accessions. Data from EMBL-EBI.

#interpro #protein-domains #protein-families #bioinformatics #annotation #pfam #life-sciences
api.oanor.com/interpro-api
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Machine-readable spec so AI agents can integrate this API.

/api/interpro-api/openapi.json
/api/interpro-api/llms.txt

Discovery: GET /api/index.json lists every API.

InterPro API — live data on the oanor API marketplace

API health

healthy
Uptime
100.00%
Server probes · 24h
Avg latency
348 ms
Server probes · 24h
Subscribers
4,610
active
Total calls
95
last 7 days
status Full status page → · 15 probes/24h

Pricing

Pick a tier — billed monthly, cancel anytime.

Free

Free

  • 510 calls / month
  • 2 requests / second
  • Hard cap (429 above quota, no overage)
  • 510 calls/month
  • 2 req/sec
  • Entries, proteins & domains
  • No credit card
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Starter

€6.95 /month

  • 18,900 calls / month
  • 6 requests / second
  • Hard cap (429 above quota, no overage)
  • 18.9k calls/month
  • 6 req/sec
  • Entry & protein lookup
  • Email support
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Pro

€21.10 /month

  • 86,500 calls / month
  • 15 requests / second
  • Hard cap (429 above quota, no overage)
  • 86.5k calls/month
  • 15 req/sec
  • Domain architecture
  • Priority support
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Mega

€57.80 /month

  • 332,000 calls / month
  • 40 requests / second
  • Hard cap (429 above quota, no overage)
  • 332k calls/month
  • 40 req/sec
  • High-throughput annotation
  • Dedicated SLA
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DNA Melting Temperature API — oanor API marketplace

DNA Melting Temperature API

DNA-oligo and PCR-primer maths as an API, computed locally and deterministically. The tm endpoint computes the melting temperature of a primer sequence three ways: the Wallace rule 2·(A+T) + 4·(G+C) for short oligos up to 13 nt, the Marmur–Wallace GC formula 64.9 + 41·(nGC − 16.4)/N for longer ones, and the salt-adjusted 81.5 + 0.41·%GC − 675/N + 16.6·log10[Na+] for a given sodium concentration, and recommends the right method for the length — an eight-base ATGCATGC melts at 24 °C by Wallace, a 20-base 50 %-GC primer at about 51.8 °C by Marmur. The gc-content endpoint reports the GC and AT percentages, the per-base counts and the single-stranded molecular weight. The reverse-complement endpoint returns the complement, the reverse and the reverse complement of a strand. Sequences use A/C/G/T (case-insensitive, whitespace ignored) and [Na+] is in mol/L. Everything is computed locally and deterministically, so it is instant and private. Ideal for molecular-biology, biotech, PCR, primer-design, bioinformatics and lab-automation app developers, oligo and primer calculators, and LIMS software. Estimation formulas for primer design, not a substitute for nearest-neighbour thermodynamics. Pure local computation — no key, no third-party service, instant. Live, nothing stored. 3 endpoints. This is oligo melting temperature; for population-genetics allele frequencies use a genetics API.

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 DNA Sequence API — oanor API marketplace

DNA Sequence API

DNA/RNA sequence-analysis maths as an API, computed locally and deterministically. The analyze endpoint reports the length and base composition of a sequence, the GC and AT content, the complement, the reverse and the reverse complement (the opposite strand read 5'→3'), and the approximate single-stranded molecular weight. The translate endpoint transcribes DNA to mRNA (T→U) and translates it to protein with the standard genetic code in reading frame 1, 2 or 3, giving the one-letter amino-acid sequence, the protein length and the number of stop codons. The melting endpoint estimates a primer's melting temperature with the Wallace rule, 4·(G+C) + 2·(A+T), for short oligos and a salt-adjusted basic formula for longer ones. Sequences are case- and whitespace-insensitive and accept A, C, G, T for DNA or U for RNA. Everything is computed locally and deterministically, so it is instant and private. Ideal for bioinformatics, molecular-biology, genomics and lab app developers, primer-design and sequence-inspection tools, and biology education. Pure local computation — no key, no third-party service, instant. Live, nothing stored. 3 endpoints. This is sequence analysis; for genome assembly data use a genomes API.

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 Genome Assemblies API — oanor API marketplace

Genome Assemblies API

Reference genome assemblies as an API — powered by NCBI Assembly, the registry of genome builds for organisms across the tree of life. Search assemblies by organism (or free text) and look up any assembly's metadata: its accession (GCF_… RefSeq or GCA_… GenBank), name (e.g. GRCh38.p14), organism and taxon id, assembly level (complete genome, chromosome, scaffold or contig), contiguity statistics (contig and scaffold N50), sequencing coverage, RefSeq category, UCSC and Ensembl names, the submitting organization, release date and FTP download paths. From the human reference genome to any sequenced microbe, plant or animal, it turns the genome-assembly registry into a clean search-and-fetch API. A genome-assembly registry — distinct from sequence (ENA), genome annotation (Ensembl), variant (ClinVar, dbVar) and gene-expression (GEO) databases. Open data from NCBI Assembly (public domain).

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 Gene Expression API — oanor API marketplace

Gene Expression API

Functional-genomics experiments as an API — powered by NCBI GEO (Gene Expression Omnibus), the largest public repository of gene-expression data. GEO archives expression series and curated datasets from microarray and high-throughput-sequencing experiments across every organism. Search experiments by keyword and optionally by organism, and look up any series or dataset to get its metadata: title, summary, assay type (expression profiling by array or by sequencing), organism, number of samples, platform and the publication behind it. From β-cell stress studies to cancer transcriptomics across human and mouse, it turns the GEO archive into a simple search-and-fetch API for transcriptomics, bioinformatics and research-data discovery. A gene-expression / functional-genomics dataset repository — distinct from sequence (ENA), variant (ClinVar, dbVar), structure (PDB) and ontology databases. Open data from NCBI GEO (public domain).

api.oanor.com/geodatasets-api

Frequently asked questions

Quick answers about pricing, quotas, and integration.

How do I get an API key for InterPro API?
Sign up for free at oanor.com, generate an API key from the developer dashboard, and call InterPro API with the x-oanor-key header. No credit card needed for the free tier.
What's the rate limit for InterPro API?
Free tier allows 1 request per second. Paid plans scale up to 50 requests per second on the Mega tier. Hard limits return HTTP 429 above the quota — no surprise overage charges.
How much does InterPro API cost?
InterPro API has a free tier with 100 calls / month. Paid plans start at €6.95 / month with higher quotas and faster rate limits.
Can I cancel my subscription anytime?
Yes. Plans are billed monthly and you can cancel anytime from your billing dashboard. No long-term contracts and no cancellation fee.
Is InterPro API GDPR-compliant?
All requests to InterPro API go through our EU-based gateway. Your upstream API key never leaves our server and no personal data is shared with the upstream provider beyond the request you send.

Pick an endpoint from the list on the left to see its details and try it.

Code snippets

Sign up to get an API key, then call any path under your slug.

curl https://api.oanor.com/interpro-api/SOME_PATH \
  -H "x-oanor-key: oanor_test_..."
const res = await fetch("https://api.oanor.com/interpro-api/SOME_PATH", {
  headers: { "x-oanor-key": "oanor_test_..." }
});
const data = await res.json();
$ch = curl_init("https://api.oanor.com/interpro-api/SOME_PATH");
curl_setopt($ch, CURLOPT_RETURNTRANSFER, true);
curl_setopt($ch, CURLOPT_HTTPHEADER, ["x-oanor-key: oanor_test_..."]);
$response = curl_exec($ch);
import requests
r = requests.get(
    "https://api.oanor.com/interpro-api/SOME_PATH",
    headers={"x-oanor-key": "oanor_test_..."},
)
print(r.json())

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