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API · /uniprot-api

UniProt API

healthy 4,282 Subscribers

The UniProt protein knowledge base as an API, powered by the official UniProt REST service curated by EMBL-EBI, SIB and PIR. Look up any protein by its UniProt accession for protein and gene names, organism, length, mass, function, keywords, Gene Ontology (GO) terms and linked PDB 3D structures; run full-text protein searches filtered by organism (NCBI taxon id) and Swiss-Prot review status; fetch amino-acid sequences with FASTA, molecular weight and CRC64 checksum; list sequence features such as signal peptides, chains, domains, active and binding sites, modified residues and natural variants, with a by-type breakdown; resolve NCBI taxonomy nodes with their full lineage; and pull reference proteomes with protein counts and genome-assembly ids. Across all kingdoms of life, from human to bacteria. Ideal for bioinformatics pipelines, drug-discovery and proteomics tools, sequence-analysis dashboards, academic research apps and life-science chatbots.

#uniprot #protein #bioinformatics #proteomics #sequence #taxonomy #life-sciences
api.oanor.com/uniprot-api
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Machine-readable spec so AI agents can integrate this API.

/api/uniprot-api/openapi.json
/api/uniprot-api/llms.txt

Discovery: GET /api/index.json lists every API.

UniProt API — live data on the oanor API marketplace

API health

healthy
Uptime
100.00%
Server probes · 24h
Avg latency
212 ms
Server probes · 24h
Subscribers
4,282
active
Total calls
140
last 7 days
status Full status page → · 28 probes/24h

Pricing

Pick a tier — billed monthly, cancel anytime.

Free

Free

  • 600 calls / month
  • 2 requests / second
  • Hard cap (429 above quota, no overage)
  • 600 calls/month
  • 2 req/sec
  • Protein, sequence & taxonomy
  • No credit card
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Starter

€6.90 /month

  • 20,000 calls / month
  • 6 requests / second
  • Hard cap (429 above quota, no overage)
  • 20k calls/month
  • 6 req/sec
  • Full-text protein search
  • Email support
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Pro

€21.50 /month

  • 90,000 calls / month
  • 15 requests / second
  • Hard cap (429 above quota, no overage)
  • 90k calls/month
  • 15 req/sec
  • Sequence features & proteomes
  • Priority support
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Mega

€59.50 /month

  • 350,000 calls / month
  • 40 requests / second
  • Hard cap (429 above quota, no overage)
  • 350k calls/month
  • 40 req/sec
  • High-throughput pipelines
  • Dedicated SLA
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Related APIs

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DNA Melting Temperature API — oanor API marketplace

DNA Melting Temperature API

DNA-oligo and PCR-primer maths as an API, computed locally and deterministically. The tm endpoint computes the melting temperature of a primer sequence three ways: the Wallace rule 2·(A+T) + 4·(G+C) for short oligos up to 13 nt, the Marmur–Wallace GC formula 64.9 + 41·(nGC − 16.4)/N for longer ones, and the salt-adjusted 81.5 + 0.41·%GC − 675/N + 16.6·log10[Na+] for a given sodium concentration, and recommends the right method for the length — an eight-base ATGCATGC melts at 24 °C by Wallace, a 20-base 50 %-GC primer at about 51.8 °C by Marmur. The gc-content endpoint reports the GC and AT percentages, the per-base counts and the single-stranded molecular weight. The reverse-complement endpoint returns the complement, the reverse and the reverse complement of a strand. Sequences use A/C/G/T (case-insensitive, whitespace ignored) and [Na+] is in mol/L. Everything is computed locally and deterministically, so it is instant and private. Ideal for molecular-biology, biotech, PCR, primer-design, bioinformatics and lab-automation app developers, oligo and primer calculators, and LIMS software. Estimation formulas for primer design, not a substitute for nearest-neighbour thermodynamics. Pure local computation — no key, no third-party service, instant. Live, nothing stored. 3 endpoints. This is oligo melting temperature; for population-genetics allele frequencies use a genetics API.

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 DNA Sequence API — oanor API marketplace

DNA Sequence API

DNA/RNA sequence-analysis maths as an API, computed locally and deterministically. The analyze endpoint reports the length and base composition of a sequence, the GC and AT content, the complement, the reverse and the reverse complement (the opposite strand read 5'→3'), and the approximate single-stranded molecular weight. The translate endpoint transcribes DNA to mRNA (T→U) and translates it to protein with the standard genetic code in reading frame 1, 2 or 3, giving the one-letter amino-acid sequence, the protein length and the number of stop codons. The melting endpoint estimates a primer's melting temperature with the Wallace rule, 4·(G+C) + 2·(A+T), for short oligos and a salt-adjusted basic formula for longer ones. Sequences are case- and whitespace-insensitive and accept A, C, G, T for DNA or U for RNA. Everything is computed locally and deterministically, so it is instant and private. Ideal for bioinformatics, molecular-biology, genomics and lab app developers, primer-design and sequence-inspection tools, and biology education. Pure local computation — no key, no third-party service, instant. Live, nothing stored. 3 endpoints. This is sequence analysis; for genome assembly data use a genomes API.

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 Genome Assemblies API — oanor API marketplace

Genome Assemblies API

Reference genome assemblies as an API — powered by NCBI Assembly, the registry of genome builds for organisms across the tree of life. Search assemblies by organism (or free text) and look up any assembly's metadata: its accession (GCF_… RefSeq or GCA_… GenBank), name (e.g. GRCh38.p14), organism and taxon id, assembly level (complete genome, chromosome, scaffold or contig), contiguity statistics (contig and scaffold N50), sequencing coverage, RefSeq category, UCSC and Ensembl names, the submitting organization, release date and FTP download paths. From the human reference genome to any sequenced microbe, plant or animal, it turns the genome-assembly registry into a clean search-and-fetch API. A genome-assembly registry — distinct from sequence (ENA), genome annotation (Ensembl), variant (ClinVar, dbVar) and gene-expression (GEO) databases. Open data from NCBI Assembly (public domain).

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 Gene Expression API — oanor API marketplace

Gene Expression API

Functional-genomics experiments as an API — powered by NCBI GEO (Gene Expression Omnibus), the largest public repository of gene-expression data. GEO archives expression series and curated datasets from microarray and high-throughput-sequencing experiments across every organism. Search experiments by keyword and optionally by organism, and look up any series or dataset to get its metadata: title, summary, assay type (expression profiling by array or by sequencing), organism, number of samples, platform and the publication behind it. From β-cell stress studies to cancer transcriptomics across human and mouse, it turns the GEO archive into a simple search-and-fetch API for transcriptomics, bioinformatics and research-data discovery. A gene-expression / functional-genomics dataset repository — distinct from sequence (ENA), variant (ClinVar, dbVar), structure (PDB) and ontology databases. Open data from NCBI GEO (public domain).

api.oanor.com/geodatasets-api

Frequently asked questions

Quick answers about pricing, quotas, and integration.

How do I get an API key for UniProt API?
Sign up for free at oanor.com, generate an API key from the developer dashboard, and call UniProt API with the x-oanor-key header. No credit card needed for the free tier.
What's the rate limit for UniProt API?
Free tier allows 1 request per second. Paid plans scale up to 50 requests per second on the Mega tier. Hard limits return HTTP 429 above the quota — no surprise overage charges.
How much does UniProt API cost?
UniProt API has a free tier with 100 calls / month. Paid plans start at €6.90 / month with higher quotas and faster rate limits.
Can I cancel my subscription anytime?
Yes. Plans are billed monthly and you can cancel anytime from your billing dashboard. No long-term contracts and no cancellation fee.
Is UniProt API GDPR-compliant?
All requests to UniProt API go through our EU-based gateway. Your upstream API key never leaves our server and no personal data is shared with the upstream provider beyond the request you send.

Pick an endpoint from the list on the left to see its details and try it.

Code snippets

Sign up to get an API key, then call any path under your slug.

curl https://api.oanor.com/uniprot-api/SOME_PATH \
  -H "x-oanor-key: oanor_test_..."
const res = await fetch("https://api.oanor.com/uniprot-api/SOME_PATH", {
  headers: { "x-oanor-key": "oanor_test_..." }
});
const data = await res.json();
$ch = curl_init("https://api.oanor.com/uniprot-api/SOME_PATH");
curl_setopt($ch, CURLOPT_RETURNTRANSFER, true);
curl_setopt($ch, CURLOPT_HTTPHEADER, ["x-oanor-key: oanor_test_..."]);
$response = curl_exec($ch);
import requests
r = requests.get(
    "https://api.oanor.com/uniprot-api/SOME_PATH",
    headers={"x-oanor-key": "oanor_test_..."},
)
print(r.json())

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