A gene's constraint & location
API · /gnomad-api
gnomAD API
healthy
3,757 Subscribers
Population genetics as an API, powered by the Broad Institute's gnomAD (Genome Aggregation Database) — allele frequencies and gene constraint aggregated from over 800,000 human exomes and genomes. Look up a gene's constraint scores (pLI, LOEUF, observed vs expected loss-of-function, missense Z) and genomic location; get a variant's allele frequencies broken down by ancestry population (African/African-American, Admixed American, Ashkenazi Jewish, East Asian, Finnish, Non-Finnish European, South Asian, Middle Eastern…) across both genome and exome callsets, with rsIDs, homozygote counts and predicted consequence; search genes by symbol; read a transcript's constraint; and list the variants in a small genomic region. Supports GRCh38 and GRCh37 and the gnomAD v4/v3/v2 datasets. Ideal for clinical and population genetics, variant interpretation and prioritisation, rare-disease and pharmacogenomics research, and bioinformatics pipelines. Variant ids are chrom-pos-ref-alt.
api.oanor.com/gnomad-api
API health
healthy- Uptime
- 100.00%
- Server probes · 24h
- Avg latency
- 255 ms
- Server probes · 24h
- Subscribers
- 3,757
- active
- Total calls
- 120
- last 7 days
Pricing
Pick a tier — billed monthly, cancel anytime.
Free
Free
- 510 calls / month
- 2 requests / second
- Hard cap (429 above quota, no overage)
- 510 calls/month
- 2 req/sec
- Genes, variants & regions
- No credit card
Starter
€7.35 /month
- 19,000 calls / month
- 6 requests / second
- Hard cap (429 above quota, no overage)
- 19k calls/month
- 6 req/sec
- Allele frequencies & constraint
- Email support
Pro
€21.80 /month
- 88,500 calls / month
- 15 requests / second
- Hard cap (429 above quota, no overage)
- 88.5k calls/month
- 15 req/sec
- Variant interpretation
- Priority support
Mega
€59.80 /month
- 342,000 calls / month
- 40 requests / second
- Hard cap (429 above quota, no overage)
- 342k calls/month
- 40 req/sec
- High-throughput population genetics
- Dedicated SLA
Built by
Related APIs
Other APIs with overlapping tags.
Structural Variants API
Human genomic structural variation as an API — powered by NCBI dbVar, the archive of structural variants (SVs): copy-number variants (CNVs), large deletions, duplications, insertions, inversions and translocations, typically larger than 50 base pairs. This is the structural counterpart to single-nucleotide variant databases: search structural variants overlapping a gene (or by free text) and get each variant's dbVar accession, the study it came from, its type, the genes it overlaps, its genomic placement on GRCh38 and its clinical significance; then look up any variant for the full record — placements on both GRCh37 and GRCh38 assemblies, variant type, genes, clinical significance, study type, methods and variant counts. From BRCA1 CNVs to Cri-du-chat deletions, it is ideal for genomics, cytogenetics, rare-disease and bioinformatics work. A structural-variation / CNV resource — distinct from clinical single-nucleotide variant interpretation (ClinVar), population allele frequencies (gnomAD) and trait associations (GWAS). Open data from NCBI dbVar (public domain).
api.oanor.com/dbvar-api
ClinVar API
ClinVar as an API, powered by the US National Library of Medicine via NCBI E-utilities. ClinVar is the public archive of the relationships between human genetic variants and health, recording the clinical significance (interpretation) of each variant — whether it is Pathogenic, Likely pathogenic, of Uncertain significance, Likely benign or Benign — together with the conditions it is associated with. /v1/search?gene=BRCA1 searches ClinVar by gene symbol, or by free text with q= (e.g. a disease or HGVS expression), returning the total number of matching variants and a list of ClinVar variation ids. /v1/variant?id=4852102 returns a variant's summary: its ClinVar accession (VCV…), title, variant type, the variation and cDNA names, the clinical classification and review status, the associated condition(s), the gene(s) and primary gene, the chromosome and location, the protein change and the molecular consequence, plus a link to the ClinVar record. Get a variation id from /v1/search, then fetch its details. Ideal for clinical-genomics and variant-annotation pipelines, rare-disease and genetic-counselling tools, and research dashboards. Data from NCBI ClinVar (public domain). This is clinical variant interpretation — distinct from population allele-frequency databases (such as gnomAD) and from protein/sequence databases. Please keep request rates modest under NCBI fair-use.
api.oanor.com/clinvar-api
Ensembl API
The Ensembl genome database as an API, powered by the official Ensembl REST service from EMBL-EBI. Look up any gene by symbol or Ensembl stable id for its biotype, genomic location, strand, description and transcripts; resolve any feature (gene, transcript, exon) by stable id; pull external database cross-references; fetch sequence variants by rsID with their alleles, most-severe consequence, minor-allele frequency, clinical significance and genomic mappings; list the genes, transcripts, exons, variations or repeats overlapping any genomic region; retrieve genomic, cDNA, CDS or protein sequences by id; and read genome-assembly metadata including the karyotype and chromosome lengths. Across human, mouse and 300+ vertebrate species. Ideal for bioinformatics pipelines, genome browsers and variant-annotation tools, genetics research apps, clinical-genomics dashboards and life-science chatbots.
api.oanor.com/ensembl-api
DNA Melting Temperature API
DNA-oligo and PCR-primer maths as an API, computed locally and deterministically. The tm endpoint computes the melting temperature of a primer sequence three ways: the Wallace rule 2·(A+T) + 4·(G+C) for short oligos up to 13 nt, the Marmur–Wallace GC formula 64.9 + 41·(nGC − 16.4)/N for longer ones, and the salt-adjusted 81.5 + 0.41·%GC − 675/N + 16.6·log10[Na+] for a given sodium concentration, and recommends the right method for the length — an eight-base ATGCATGC melts at 24 °C by Wallace, a 20-base 50 %-GC primer at about 51.8 °C by Marmur. The gc-content endpoint reports the GC and AT percentages, the per-base counts and the single-stranded molecular weight. The reverse-complement endpoint returns the complement, the reverse and the reverse complement of a strand. Sequences use A/C/G/T (case-insensitive, whitespace ignored) and [Na+] is in mol/L. Everything is computed locally and deterministically, so it is instant and private. Ideal for molecular-biology, biotech, PCR, primer-design, bioinformatics and lab-automation app developers, oligo and primer calculators, and LIMS software. Estimation formulas for primer design, not a substitute for nearest-neighbour thermodynamics. Pure local computation — no key, no third-party service, instant. Live, nothing stored. 3 endpoints. This is oligo melting temperature; for population-genetics allele frequencies use a genetics API.
api.oanor.com/dnamelt-api
Frequently asked questions
Quick answers about pricing, quotas, and integration.
How do I get an API key for gnomAD API?
Sign up for free at oanor.com, generate an API key from the developer dashboard, and call gnomAD API with the x-oanor-key header. No credit card needed for the free tier.
What's the rate limit for gnomAD API?
Free tier allows 1 request per second. Paid plans scale up to 50 requests per second on the Mega tier. Hard limits return HTTP 429 above the quota — no surprise overage charges.
How much does gnomAD API cost?
gnomAD API has a free tier with 100 calls / month. Paid plans start at €7.35 / month with higher quotas and faster rate limits.
Can I cancel my subscription anytime?
Yes. Plans are billed monthly and you can cancel anytime from your billing dashboard. No long-term contracts and no cancellation fee.
Is gnomAD API GDPR-compliant?
All requests to gnomAD API go through our EU-based gateway. Your upstream API key never leaves our server and no personal data is shared with the upstream provider beyond the request you send.
Pick an endpoint from the list on the left to see its details and try it.
Code snippets
Sign up to get an API key, then call any path under your slug.
curl https://api.oanor.com/gnomad-api/SOME_PATH \
-H "x-oanor-key: oanor_test_..."const res = await fetch("https://api.oanor.com/gnomad-api/SOME_PATH", {
headers: { "x-oanor-key": "oanor_test_..." }
});
const data = await res.json();$ch = curl_init("https://api.oanor.com/gnomad-api/SOME_PATH");
curl_setopt($ch, CURLOPT_RETURNTRANSFER, true);
curl_setopt($ch, CURLOPT_HTTPHEADER, ["x-oanor-key: oanor_test_..."]);
$response = curl_exec($ch);import requests
r = requests.get(
"https://api.oanor.com/gnomad-api/SOME_PATH",
headers={"x-oanor-key": "oanor_test_..."},
)
print(r.json())Ratings
Sign in to rate.
No reviews yet.
Discussion
Ask questions, share usage tips, get answers from the provider and other developers. Public — anyone can read.
Sign in to start a thread or reply.
Sign inNew thread
📌 Pinned
🔒 Locked
·
·
·
-
Provider answer
🔒 This thread is locked — no new replies.
-
·
- No threads yet — start the discussion.
Support
Private 1:1 support with the provider — billing questions, integration issues, account problems. Only you and the provider team can see these threads.
Sign in to open a support ticket.
Sign inOpen new ticket
Describe what you need help with. The provider team gets an email and replies on the ticket page.
-
·
Urgent - No tickets yet for this API.